Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.55 |
| ▸ | PLK1 | P53350 | 12/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | TTK | P33981 | 1/20 | 0.54 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 7/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.48 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538104 | 0.92 | PLK1 (0.60) | PLK1TTKRAD52BRD4BRDT | |
| SCHEMBL3543923 | 0.89 | ALK (0.72) | ALKPLK1RAD52BRD4BRDT | |
| SCHEMBL3538446 | 0.87 | ALK (0.67) | ALKPLK1RAD52BRD4BRDT | |
| SCHEMBL3541656 | 0.87 | ALK (0.65) | ALKPLK1PLK3RAD52BRD4 | |
| SCHEMBL3545300 | 0.86 | ALK (0.61) | ALKPLK1PLK3RAD52BRD4 | |
| SCHEMBL1560601 | 0.85 | PLK1 (0.55) | ALKPLK1PLK3BRD4IGF1R | |
| SCHEMBL3540809 | 0.85 | PLK1 (0.74) | ALKPLK1PLK3PLK4GAK | |
| SCHEMBL14313607 | 0.83 | PLK1 (0.61) | PLK1PLK3TTKRAD52BRD4 | |
| SCHEMBL1203486 | 0.81 | PLK1 (0.77) | ALKPLK1PLK3GAKTTK | |
| SCHEMBL3670801 | 0.81 | RAD52 (0.66) | ALKPLK1PLK3GAKTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709471-B2 | Compounds | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20080009482-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009482-A1 | NOVEL COMPOUNDS | CYP11B2, CYP11B1, CYP46A1 | ALK 4405/4885PLK1 847/4885PLK3 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.