⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643498 | 1.00 | — | — | |
| SCHEMBL3549918 | 1.00 | — | — | |
| SCHEMBL18960787 | 1.00 | — | — | |
| SCHEMBL9663942 | 1.00 | — | — | |
| SCHEMBL9666157 | 1.00 | — | — | |
| Water SCHEMBL10645090 | 0.99 | — | — | |
| Water SCHEMBL10642998 | 0.99 | — | — | |
| Water SCHEMBL10643003 | 0.99 | — | — | |
| Water SCHEMBL10645046 | 0.99 | — | — | |
| Water SCHEMBL10644388 | 0.99 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291304-B1 | PROCESS FOR THE CONVERSION OF THE E-ISOMER OF 6-(SUBSTITUTED METHYLENE)-2-PENEMS INTO THE Z-ISOMER | BEECHAM GROUP PLC (GB) | 1992-02-26 | — | — | EP | claimed |
| EP-0291304-A1 | Process for the conversion of the E-isomer of 6-(substituted methylene)-2-penems into the Z-isomer | BEECHAM GROUP PLC (GB) | 1988-11-17 | — | — | EP | claimed |
| US-4774238-A | BACTERICIDES, BETA-LACTAMASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1988-09-27 | — | — | US | claimed |
| EP-0210814-A1 | 6-(Substituted methylene) penems | BEECHAM GROUP PLC (GB) | 1987-02-04 | — | — | EP | claimed |
| US-7812014-B2 | Bicyclic 6-alkylidene-penems as β-lactamase inhibitors | WYETH LLC (US) | 2010-10-12 | — | — | US | disclosed |
| US-7691842-B2 | Tricyclic 6-alkylidene-penems as β-lactamase inhibitors | WYETH LLC (US) | 2010-04-06 | — | — | US | disclosed |
| EP-1499622-B1 | HETEROTRICYCLYL 6-ALKYLIDENE-PENEMS AS BETA-LACTAMASE INHIBITORS | WYETH CORP (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20080318921-A1 | Tricyclic 6-Alkylidene-Penems as Beta-Lactamase Inhibitors | WYETH (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080312203-A1 | Bicyclic 6-Alkylidene-Penems as Beta-Lactamase Inhibitors | WYETH (US) | 2008-12-18 | — | — | US | disclosed |
| EP-1988093-A1 | Bicyclic 6-alkylidene-penems as beta-lactamases inhibitors | Wyeth a Corporation of the State of Delaware (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20060217361-A1 | Bicyclic 6-alkylidene-penems as beta-lactamase inhibitors | WYETH (US) | 2006-09-28 | — | — | US | disclosed |
| US-7112582-B2 | Bicyclic 6-alkylidene-penems as β-lactamase inhibitors | WYETH (US) | 2006-09-26 | — | — | US | disclosed |
| EP-0154132-B1 | 6-ALKYLIDENE PENEMS, THEIR PREPARATION AND USE, AND INTERMEDIATES | BEECHAM GROUP PLC (GB) | 1992-01-08 | — | — | EP | disclosed |
| US-4897476-A | Process for preparing penems | BEECHAM GROUP P.L.C. (GB) | 1990-01-30 | — | — | US | disclosed |
| US-4798828-A | LACTAMASE INHIBITORS | BEECHAM GROUP P.L.C. (GB) | 1989-01-17 | — | — | US | disclosed |
| EP-0291304-A1 | Process for the conversion of the E-isomer of 6-(substituted methylene)-2-penems into the Z-isomer | BEECHAM GROUP PLC (GB) | 1988-11-17 | — | — | EP | disclosed |
| US-4774238-A | BACTERICIDES, BETA-LACTAMASE INHIBITORS | BEECHAM GROUP PLC (GB) | 1988-09-27 | — | — | US | disclosed |
| EP-0232966-A1 | Process for the preparation of penem compounds and intermediates for this preparation | BEECHAM GROUP PLC (GB) | 1987-08-19 | — | — | EP | disclosed |
| EP-0210814-A1 | 6-(Substituted methylene) penems | BEECHAM GROUP PLC (GB) | 1987-02-04 | — | — | EP | disclosed |
| EP-0154132-A1 | 6-Alkylidene penems, their preparation and use, and intermediates | BEECHAM GROUP PLC (GB) | 1985-09-11 | — | — | EP | disclosed |