Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | ADK | P55263 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3542865 | 0.99 | KCNH2 (0.46) | KCNH2ADKALDH1A1HSD17B10MEN1 | |
| SCHEMBL3546019 | 0.90 | CHRM2 (0.39) | KCNH2ADKTLR7NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL3549839 | 0.89 | CHRM2 (0.38) | KCNH2ADKTLR7NOS3NOS1 | |
| SCHEMBL3552355 | 0.82 | HTR1D (0.44) | — | |
| SCHEMBL5011660 | 0.82 | KDM4E (0.47) | KCNH2ALDH1A1MEN1KMT2ATLR7 | |
| Hydrochloric Acid SCHEMBL3552414 | 0.81 | HTR1D (0.43) | — | |
| Hydrochloric Acid SCHEMBL5016044 | 0.81 | KDM4E (0.47) | KCNH2ALDH1A1MEN1KMT2ATLR7 | |
| SCHEMBL3546928 | 0.81 | TLR9 (0.36) | ALDH1A1HSD17B10MEN1KMT2ATLR7 | |
| SCHEMBL3547845 | 0.81 | ALDH1A1 (0.39) | ALDH1A1HSD17B10MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL3547583 | 0.80 | TLR9 (0.36) | ALDH1A1HSD17B10MEN1KMT2ATLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741343-B2 | 6H-oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2010-06-22 | — | — | US | disclosed |
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | SCHIEMANN KAI | 2008-02-28 | — | — | US | disclosed |
| US-7291633-B2 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2007-11-06 | — | — | US | disclosed |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | US | disclosed |
| EP-1392699-B1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | disclosed |
| EP-1392699-A1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GmbH (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002088139-A1 | 6H-OXAZOLO[4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | KCNH2 2522/4885ADK 2978/4885ALDH1A1 2637/4885 |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | KCNH2 2758/4885ADK 2827/4885ALDH1A1 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.