SCHEMBL3551909

SCHEMBL3551909

Nc1cc(C2CCCC2)[nH]n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.49
DAO P14920 2/20 0.42
MKNK1 Q9BUB5 3/20 0.42
MKNK2 Q9HBH9 3/20 0.42
CCNA2 P20248 4/20 0.40
CDK2 P24941 4/20 0.40
CCNA1 P78396 4/20 0.40
HCAR3 P49019 1/20 0.40
HRH4 Q9H3N8 1/20 0.38
DRD2 P14416 1/20 0.38
DRD4 P21917 1/20 0.38
DRD3 P35462 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC10 Q969S8 1/20 0.38
HDAC11 Q96DB2 1/20 0.38
HDAC8 Q9BY41 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29327040 0.98 HCAR2 (0.47) HCAR2DAOMKNK1MKNK2CCNA2
SCHEMBL16247075 0.98 HCAR2 (0.47) HCAR2DAOMKNK1MKNK2CCNA2
Hydrochloric Acid SCHEMBL17398190 0.96 HCAR2 (0.46) HCAR2DAOMKNK1MKNK2CCNA2
SCHEMBL1269829 0.96 HCAR2 (0.53) HCAR2DAOMKNK1MKNK2CCNA2
SCHEMBL56939 0.91
Hydrochloric Acid SCHEMBL17107724 0.89 HCAR2 (0.48) HCAR2DAOMKNK1MKNK2CCNA2
SCHEMBL12184926 0.84 MKNK1 (0.57) HCAR2MKNK1MKNK2HCAR3HRH4
SCHEMBL4016705 0.82 DAO (0.47) HCAR2DAOMKNK1MKNK2CCNA2
SCHEMBL31080297 0.81 HCAR2 (0.37) HCAR2MKNK1MKNK2HCAR3
SCHEMBL17001818 0.80 DRD4 (0.55) HCAR2MKNK1MKNK2DRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12551482-B2 Aurora kinase inhibitors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2026-02-17 US disclosed
US-12545649-B2 WDR5-MYC inhibitors VANDERBILT UNIVERSITY (US) 2026-02-10 US disclosed
US-20250177393-A1 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN NALO THERAPEUTICS (US) 2025-06-05 US disclosed
US-20250170130-A1 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN NALO THERAPEUTICS (US) 2025-05-29 US disclosed
WO-2025043063-A1 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN NALO THERAPEUTICS, INC. (US) 2025-02-27 WO disclosed
CN-119053590-A Modulators of MYC family protooncogene proteins 纳罗医疗公司 2024-11-29 CN disclosed
WO-2024206628-A1 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN NALO THERAPEUTICS (US) 2024-10-03 WO disclosed
WO-2023164612-A9 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN NALO THERAPEUTICS (US) 2024-05-30 WO disclosed
WO-2023164612-A9 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN NALO THERAPEUTICS (US) 2024-05-30 WO disclosed
CN-113493436-B Amino substituted pyridine derivative and preparation method thereof, pharmaceutical composition and application 中国医学科学院药物研究所 2023-10-20 CN disclosed
WO-2013026914-A1 SERINE/THREONINE PAK1 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2013-02-28 WO disclosed
CN-1934113-B Compositions useful as protein kinase inhibitors VERTEX PHARMA CO LTD 2011-11-09 CN disclosed
US-7855214-B2 Fused cyclic systems useful as inhibitors of TEC family protein kinases VERTEX PHARMACEUTICALS INCORPORATED (US) 2010-12-21 US disclosed
CN-1934113-A Compositions useful as protein kinase inhibitors VERTEX PHARMA (US) 2007-03-21 CN disclosed
EP-1716151-A1 COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES Vertex Pharmaceuticals Incorporated (US) 2006-11-02 EP disclosed
WO-2005095406-A1 COMPOSITIONS USEFUL AS INHIBITORS OF PROTEIN KINASES VERTEX PHARMACEUTICALS INCORPORATED (US) 2005-10-13 WO disclosed
US-20050209255-A1 Compositions useful as inhibitors of protein kinases VERTEX PHARMACEUTICALS INCORPORATED 2005-09-22 US disclosed
US-20040116497-A1 Chromane derivatives, process for their preparation and their use as antitumor agents PHARMACIA ITALIA SPA (IT) 2004-06-17 US disclosed
EP-1379524-A2 CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2004-01-14 EP disclosed
WO-2002070515-A2 CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2002-09-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12545649-B2 WDR5-MYC inhibitors MYC, MYCBP, WDR1 HCAR2 3268/4885DAO 3370/4885MKNK1 657/4885
US-20250177393-A1 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN MYC, MYCBP, MYCBP2 HCAR2 4842/4885DAO 3881/4885MKNK1 124/4885
US-12551482-B2 Aurora kinase inhibitors MYC, AURKA, AURKC HCAR2 4781/4885DAO 4384/4885MKNK1 65/4885
US-20250170130-A1 MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN MYC, MYCBP, MYCBP2 HCAR2 4842/4885DAO 3881/4885MKNK1 124/4885
US-20050209255-A1 Compositions useful as inhibitors of protein kinases MAP3K20, PACSIN2, MAP3K1 HCAR2 4650/4885DAO 3715/4885MKNK1 57/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.