Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PDE5A | O76074 | 16/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027970 | 0.93 | POLB (0.61) | ALDH1A1POLBPDE5APDE1APDE1B | |
| SCHEMBL3550241 | 0.91 | POLB (0.57) | ALDH1A1POLBPDE5APDE1APDE1B | |
| SCHEMBL3388828 | 0.91 | POLB (0.59) | ALDH1A1POLBPDE5APDE1APDE1B | |
| SCHEMBL13348812 | 0.86 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3012296 | 0.85 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3547443 | 0.83 | PDE5A (0.57) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3027973 | 0.83 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3026814 | 0.82 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3027989 | 0.82 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3031282 | 0.81 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745433-B2 | 2-Substituted phenyl-5, 7-dihydrocarbyl-3, 7-dihydropyrrolo [2, 3-D] pyrimidin-4-one derivatives, the preparation and the pharmaceutical use thereof | Yangtze River Pharmacuetical (Group) Co., Ltd. (CN) | 2010-06-29 | — | — | US | claimed |