Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.57 |
| ▸ | PDE1A | P54750 | 2/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | PDE9A | O76083 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027989 | 0.93 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3027973 | 0.88 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3023331 | 0.88 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3028372 | 0.87 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3029660 | 0.86 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL13348812 | 0.85 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL3017892 | 0.85 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL3012296 | 0.84 | PDE5A (0.55) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL3552285 | 0.83 | ALDH1A1 (0.59) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL3027970 | 0.83 | POLB (0.61) | PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745433-B2 | 2-Substituted phenyl-5, 7-dihydrocarbyl-3, 7-dihydropyrrolo [2, 3-D] pyrimidin-4-one derivatives, the preparation and the pharmaceutical use thereof | Yangtze River Pharmacuetical (Group) Co., Ltd. (CN) | 2010-06-29 | — | — | US | claimed |