Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.64 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | ESRRG | P62508 | 6/20 | 0.44 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ESRRB | O95718 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563410 | 0.95 | HRH3 (0.70) | HRH3HRH1CYP2D6 | |
| SCHEMBL2563611 | 0.95 | HRH3 (0.70) | HRH3HRH1CYP2D6 | |
| SCHEMBL2560963 | 0.95 | HRH3 (0.70) | HRH3HRH1CYP2D6 | |
| Hydrochloric Acid SCHEMBL3552392 | 0.94 | HRH3 (0.69) | HRH3HRH1ESRRGESR1CYP2D6 | |
| SCHEMBL2560471 | 0.94 | HRH3 (0.72) | HRH3HRH1CYP2D6 | |
| Oxalic Acid SCHEMBL3554944 | 0.87 | HRH3 (0.49) | HRH3HRH1ESRRGESR1ESRRB | |
| SCHEMBL5223664 | 0.82 | HRH3 (0.55) | HRH3HRH1KDM4E | |
| SCHEMBL2564836 | 0.82 | HRH3 (0.55) | HRH3HRH1KDM4E | |
| SCHEMBL2564050 | 0.82 | HRH3 (0.55) | HRH3HRH1ESRRGESR1KDM4E | |
| SCHEMBL2564277 | 0.81 | HRH3 (0.52) | HRH3HRH1ESRRGESR1ESRRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678807-B2 | Isoquinoline and benzo[H] isoquinoline derivatives, preparation and therapeutic use thereof as antagonists of the histamine H3 receptor | SANOFI-AVENTIS (FR) | 2010-03-16 | — | — | US | disclosed |
| US-20080269199-A1 | ISOQUINOLINE AND BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF THE HISTAMINE H3 RECEPTOR | SANOFI-AVENTIS (FR) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269199-A1 | ISOQUINOLINE AND BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH1, HRH2 | HRH3 1/4885HRH1 2/4885ESRRG 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.