Sugi Predict

Sugi Predict / Compounds / SCHEMBL355353

SCHEMBL355353

SCHEMBL355353

CC(C)[C@H](N)C(=O)NC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 5/20 0.47
▸ DPP8 Q6V1X1 2/20 0.47
▸ DPP9 Q86TI2 2/20 0.47
▸ DPP7 Q9UHL4 2/20 0.47
▸ FAP Q12884 1/20 0.47
▸ SLC7A5 Q01650 1/20 0.44
▸ POLB P06746 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA7 P43166 1/20 0.33
▸ CA14 Q9ULX7 1/20 0.33
▸ EPHX1 P07099 1/20 0.32
▸ LAP3 P28838 1/20 0.32
▸ CXCL8 P10145 1/20 0.31
▸ TRPA1 O75762 1/20 0.31
▸ MEN1 O00255 2/20 0.31
▸ KMT2A Q03164 2/20 0.31
▸ CIT O14578 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10451323 1.00 DPP4 (0.47) DPP4DPP8DPP9DPP7FAP
SCHEMBL23975825 1.00 DPP4 (0.47) DPP4DPP8DPP9DPP7FAP
Hydrochloric Acid SCHEMBL356236 0.98 DPP4 (0.45) DPP4DPP8DPP9DPP7FAP
SCHEMBL3258317 0.87 POLB (0.39) DPP4DPP8DPP9DPP7FAP
SCHEMBL24543396 0.86 POLB (0.40) DPP4DPP8DPP9DPP7FAP
SCHEMBL24543161 0.86 POLB (0.40) DPP4DPP8DPP9DPP7FAP
SCHEMBL12234234 0.86 POLB (0.40) DPP4DPP8DPP9DPP7FAP
SCHEMBL24543397 0.86 POLB (0.40) DPP4DPP8DPP9DPP7FAP
SCHEMBL23958917 0.86 DPP4 (0.48) DPP4DPP8DPP9DPP7FAP
SCHEMBL23958961 0.86 DPP4 (0.48) DPP4DPP8DPP9DPP7FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9272261-B2 Organic-inorganic hybrid chiral sorbent and process for the preparation thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2016-03-01 — — US disclosed
EP-2066440-B1 PROCESS FOR THE PREPARATION OF ORGANIC-INORGANIC HYBRID CHIRAL SORBENT , SORBENT OBTAINED BY THE PROCESS AND USE THEREOF FOR SEPARATING RACEMIC MIXTURES COUNCIL SCIENT IND RES (IN) 2015-09-09 — — EP disclosed
US-20140329746-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2014-11-06 — — US disclosed
US-8835654-B2 Method and compositions for treating amyloid-related diseases BHI LIMITED PARTNERSHIP (CA) 2014-09-16 — — US disclosed
US-20140107027-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES BHI LIMITED PARTNERSHIP (CA) 2014-04-17 — — US disclosed
US-8642801-B2 Methods and compositions for treating amyloid-related diseases BHI LIMITED PARTNERSHIP (CA) 2014-02-04 — — US disclosed
US-20130317244-A1 ORGANIC-INORGANIC HYBRID CHIRAL SORBENT AND PROCESS FOR THE PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2013-11-28 — — US disclosed
US-8586552-B2 4,6-substituted 2,5-dideoxystreptamine aminoglycoside antibiotics SELECTX PHARMACEUTICALS, INC. (US) 2013-11-19 — — US disclosed
EP-1619189-B1 N-(3-acyl-2-hydroxyalkyl) cycloalkyl amide derivatives SEIKAGAKU KOGYO CO LTD (JP) 2013-09-04 — — EP disclosed
EP-1619189-B1 N-(3-acyl-2-hydroxyalkyl) cycloalkyl amide derivatives SEIKAGAKU KOGYO CO LTD (JP) 2013-09-04 — — EP disclosed
US-5164314-A Reduction of diacetyl to optically active acetoin FORSCHUNGSZENTRUM JUELICH GMBH (DE) 1992-11-17 — — US disclosed
US-5154738-A Passing mixture through gas chromatography column having dialkyl trifluoroacyl ether derivative of cyclodextrin, eluting separated compounds ADVANCED SEPARATION TECHNOLOGIES, INC. (US) 1992-10-13 — — US disclosed
EP-0494967-A1 CHIRAL SEPARATION MEDIA ADVANCED SEPARATION TECHNOLOGIES, INC. (US) 1992-07-22 — — EP disclosed
WO-1992002283-A1 CHIRAL SEPARATION MEDIA ADVANCED SEPARATION TECHNOLOGIES INC. (US) 1992-02-20 — — WO disclosed
US-5064944-A Gas Chromatography ADVANCED SEPARATION TECHNOLOGIES INC. (US) 1991-11-12 — — US disclosed
US-4948395-A Permethylated hydroxy ehters of cyclodextrins ADVANCED SEPARATIONS TECHNOLOGIES INC. (US) 1990-08-14 — — US disclosed
US-4909935-A Chromatographic arylcarboxamide polysiloxanes BRIGHAM YOUNG UNIVERSITY (US) 1990-03-20 — — US disclosed
EP-0182170-B1 A PROCESS FOR THE RESOLUTION OF A RACEMATE Laporte Industries Limited (GB) 1990-02-28 — — EP disclosed
US-4687871-A ADSORPTION ON A CRYSTALLINE MOLECULAR SIEVES LAPORTE INDUSTRIES LIMITED (GB) 1987-08-18 — — US disclosed
EP-0182170-A2 A process for the resolution of a racemate Laporte Industries Limited (GB) 1986-05-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140329746-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES APP, PSEN1, PSEN2 DPP4 888/4885DPP8 924/4885DPP9 777/4885
US-20140107027-A1 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES APP, PSEN1, PSEN2 DPP4 888/4885DPP8 924/4885DPP9 777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.