Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.81 |
| ▸ | CSF1R | P07333 | 3/20 | 0.63 |
| ▸ | CDK4 | P11802 | 3/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.63 |
| ▸ | CDK1 | P06493 | 5/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3546255 | 0.94 | CDK2 (0.77) | CDK2KCNH2CSF1RCDK4CDK6 | |
| SCHEMBL3548395 | 0.90 | CDK2 (1.00) | CDK2KCNH2CDK1 | |
| SCHEMBL3544746 | 0.89 | CDK2 (0.64) | CDK2KCNH2CSF1RCDK4CDK6 | |
| SCHEMBL4245350 | 0.87 | CDK2 (0.81) | CDK2KCNH2CDK1 | |
| SCHEMBL3547318 | 0.86 | CDK2 (0.76) | CDK2KCNH2CDK4CDK6CDK1 | |
| SCHEMBL3552047 | 0.86 | CDK2 (0.67) | CDK2KCNH2CDK1 | |
| SCHEMBL3551853 | 0.84 | CDK2 (0.63) | CDK2KCNH2CSF1RCDK4CDK6 | |
| SCHEMBL4246956 | 0.83 | CDK2 (0.71) | CDK2KCNH2CDK1 | |
| SCHEMBL1448607 | 0.83 | CDK2 (0.70) | CDK2KCNH2CSF1RCDK4CDK6 | |
| SCHEMBL30928955 | 0.83 | CDK4 (0.67) | CDK2KCNH2CSF1RCDK4CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655652-B2 | 2-{4-[4-(2-hydroxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-5-fluoropyrimidine hydrochloride; cell cycle inhibitory; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161615-A1 | Chemical compounds | MKI67, PCNA, CCNI | CDK2 84/4885KCNH2 4616/4885CSF1R 3118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.