Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980819 | 0.86 | MAPT (1.00) | MAPTPOLBLMNAHPGDPKM | |
| SCHEMBL3556358 | 0.82 | MAPT (0.61) | MAPTPOLBLMNAHPGDPKM | |
| SCHEMBL3555247 | 0.79 | NPC1 (0.58) | MAPTPOLBLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL10566391 | 0.76 | MAPT (0.61) | MAPTPOLBLMNAMEN1KMT2A | |
| SCHEMBL13861476 | 0.76 | MAPT (0.61) | MAPTPOLBLMNAHPGDPKM | |
| SCHEMBL11464576 | 0.74 | MAPT (0.59) | MAPTPOLBLMNAHPGDPKM | |
| Hydrochloric Acid SCHEMBL4931737 | 0.71 | MAPT (0.56) | MAPTPOLBLMNAHPGDMEN1 | |
| SCHEMBL11820340 | 0.71 | MAPT (0.55) | MAPTPOLBLMNAHPGDMEN1 | |
| SCHEMBL17209588 | 0.70 | MAPT (0.54) | MAPTPOLBLMNAHPGDMEN1 | |
| SCHEMBL12230248 | 0.69 | MAPT (0.52) | MAPTPOLBLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732452-B2 | Thiophene derivatives which are HM74A agonists | HOFFMANN-LA ROCHE INC. (US) | 2010-06-08 | — | — | US | claimed |