Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24716328 | 0.86 | ALDH1A1 (0.53) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL28892278 | 0.85 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL24716983 | 0.83 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL30829721 | 0.83 | ALDH1A1 (0.49) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL28670512 | 0.83 | ALDH1A1 (0.51) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL3553922 | 0.82 | MAPT (0.76) | MAPTLMNAPOLBALDH1A1KDM4E | |
| SCHEMBL3555247 | 0.81 | NPC1 (0.58) | MAPTLMNAPOLBALDH1A1CYP1A2 | |
| SCHEMBL3980819 | 0.76 | MAPT (1.00) | MAPTLMNAPOLBALDH1A1KDM4E | |
| SCHEMBL15880510 | 0.75 | L3MBTL1 (0.66) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL3783571 | 0.74 | KDM4E (0.78) | MAPTLMNAPOLBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732452-B2 | Thiophene derivatives which are HM74A agonists | HOFFMANN-LA ROCHE INC. (US) | 2010-06-08 | — | — | US | claimed |