Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.74 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554000 | 1.00 | TERT (0.74) | TERTLTB4RKDM4EPTPN1SMN1; SMN2 | |
| SCHEMBL6786329 | 0.89 | TERT (0.61) | TERTLTB4RKDM4EPTPN1LMNA | |
| SCHEMBL30760782 | 0.85 | TERT (1.00) | TERTLTB4RKDM4EMEN1KMT2A | |
| SCHEMBL16964998 | 0.85 | TERT (1.00) | TERTLTB4RKDM4EMEN1KMT2A | |
| SCHEMBL29355750 | 0.85 | TERT (1.00) | TERTLTB4RKDM4EMEN1KMT2A | |
| SCHEMBL6783614 | 0.85 | TERT (0.81) | TERTLTB4RKDM4EPTPN1SMN1; SMN2 | |
| SCHEMBL29362821 | 0.85 | TERT (1.00) | TERTLTB4RKDM4EMEN1KMT2A | |
| SCHEMBL29966843 | 0.85 | TERT (1.00) | TERTLTB4RKDM4EMEN1KMT2A | |
| SCHEMBL4022937 | 0.85 | TERT (1.00) | TERTLTB4RKDM4EMEN1KMT2A | |
| SCHEMBL6783732 | 0.83 | TERT (0.85) | TERTLTB4RKDM4EPTPN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732452-B2 | Thiophene derivatives which are HM74A agonists | HOFFMANN-LA ROCHE INC. (US) | 2010-06-08 | — | — | US | claimed |