Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.70 |
| ▸ | CDK4 | P11802 | 5/20 | 0.57 |
| ▸ | CCND1 | P24385 | 3/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.57 |
| ▸ | CDK1 | P06493 | 2/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.57 |
| ▸ | CCND2 | P30279 | 2/20 | 0.57 |
| ▸ | CCND3 | P30281 | 2/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549603 | 0.90 | CDK4 (0.59) | CDK2KCNH2CDK4CCND1CCNB2 | |
| SCHEMBL4247804 | 0.88 | CDK4 (0.62) | CDK2KCNH2CDK4CCND1CDK1 | |
| SCHEMBL3549927 | 0.87 | CDK4 (0.61) | CDK2KCNH2CDK4CCND1CDK1 | |
| SCHEMBL3548395 | 0.83 | CDK2 (1.00) | CDK2KCNH2CDK1SYKJAK2 | |
| SCHEMBL3549674 | 0.83 | CDK2 (0.69) | CDK2KCNH2CDK4CCND1CCNB2 | |
| SCHEMBL634564 | 0.83 | CDK2 (0.55) | CDK2KCNH2CDK4CCND1CDK1 | |
| SCHEMBL4296568 | 0.82 | CDK2 (0.54) | CDK2KCNH2CDK1SYKJAK2 | |
| SCHEMBL13878981 | 0.82 | CDK2 (0.54) | CDK2KCNH2CDK4CCND1CDK1 | |
| Hydrochloric Acid SCHEMBL3552921 | 0.82 | CDK2 (0.72) | CDK2KCNH2CDK4CCND1CDK1 | |
| SCHEMBL3944162 | 0.82 | CDK2 (0.59) | CDK2KCNH2CDK1SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655652-B2 | 2-{4-[4-(2-hydroxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-5-fluoropyrimidine hydrochloride; cell cycle inhibitory; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161615-A1 | Chemical compounds | MKI67, PCNA, CCNI | CDK2 84/4885KCNH2 4616/4885CDK4 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.