Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.69 |
| ▸ | JAK2 | O60674 | 10/20 | 0.57 |
| ▸ | CDK4 | P11802 | 6/20 | 0.57 |
| ▸ | CDK1 | P06493 | 4/20 | 0.57 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.57 |
| ▸ | CCND1 | P24385 | 2/20 | 0.57 |
| ▸ | CCND2 | P30279 | 2/20 | 0.57 |
| ▸ | CCND3 | P30281 | 2/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 4/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.56 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | CDK9 | P50750 | 3/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3547575 | 0.87 | KCNH2 (0.73) | CDK2JAK2CDK4CDK1CCNB1 | |
| SCHEMBL1447630 | 0.85 | CDK2 (0.69) | CDK2JAK2CDK1PLK4KCNH2 | |
| SCHEMBL4030132 | 0.83 | CDK2 (0.68) | CDK2CDK4CDK1CCNB1CCND1 | |
| SCHEMBL3554221 | 0.83 | CDK2 (0.70) | CDK2JAK2CDK4CDK1CCNB2 | |
| SCHEMBL3551055 | 0.82 | CDK2 (1.00) | CDK2JAK2CDK4CDK1CCNB1 | |
| SCHEMBL3937072 | 0.82 | JAK2 (0.57) | CDK2JAK2CDK4AURKAAURKB | |
| SCHEMBL4193367 | 0.81 | CDK2 (0.71) | CDK2CDK4CCND1CCND2CCND3 | |
| SCHEMBL1447357 | 0.81 | CDK2 (0.60) | CDK2CDK4CDK1CCNB1CDK9 | |
| SCHEMBL4251013 | 0.81 | CDK2 (0.63) | CDK2JAK2CDK4CDK1CCNB1 | |
| SCHEMBL4246230 | 0.80 | CDK2 (0.57) | CDK2CDK4CDK1CCNB1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655652-B2 | 2-{4-[4-(2-hydroxyacetyl)piperazin-1-yl]anilino}-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-5-fluoropyrimidine hydrochloride; cell cycle inhibitory; rheumatoid arthritis | ASTRAZENECA AB (SE) | 2010-02-02 | — | — | US | disclosed |
| US-20070161615-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161615-A1 | Chemical compounds | MKI67, PCNA, CCNI | CDK2 84/4885JAK2 2635/4885CDK4 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.