⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133796 | 0.93 | — | — | |
| SCHEMBL23829885 | 0.77 | — | — | |
| SCHEMBL10414797 | 0.75 | — | — | |
| SCHEMBL7439432 | 0.73 | — | — | |
| SCHEMBL12013049 | 0.70 | — | — | |
| SCHEMBL11528812 | 0.64 | POLB (0.43) | — | |
| SCHEMBL983745 | 0.58 | — | — | |
| SCHEMBL302276 | 0.58 | — | — | |
| SCHEMBL1363715 | 0.58 | — | — | |
| SCHEMBL788760 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111675706-A | Isothiazole bithiazole amide derivatives, and preparation method and application thereof | 南开大学 | 2020-09-18 | — | — | CN | claimed |
| CN-1785981-A | N-substituted phenyl-2-oxo-1, 3-thiazolidine-3-formamide derirative, preparation method and its use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2006-06-14 | — | — | CN | claimed |
| US-4158004-A | Process for antibiotic FR 1923 and related compounds | ELI LILLY AND COMPANY (US) | 1979-06-12 | — | — | US | claimed |
| CN-111675706-A | Isothiazole bithiazole amide derivatives, and preparation method and application thereof | 南开大学 | 2020-09-18 | — | — | CN | disclosed |
| CN-104610230-A | Compounds for the treatment of cancer | UNIV TENNESSEE RES FOUNDATION | 2015-05-13 | — | — | CN | disclosed |
| CN-102137592-B | Compounds for the treatment of cancer | UNIV TENNESSEE RES FOUNDATION (US) | 2015-01-28 | — | — | CN | disclosed |
| US-7662842-B2 | Thiazolidinone amides, thiazolidine carboxylic acid amides, and serine amides, including polyamine conjugates thereof, as selective anti-cancer agents | Ohio State Univesity Research Foundation (US) | 2010-02-16 | — | — | US | disclosed |
| US-20090143446-A1 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, METHODS OF MAKING, AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2009-06-04 | — | — | US | disclosed |
| EP-1646383-A4 | DESIGN AND SYNTHESIS OF OPTIMIZED LIGANDS FOR PPAR | BETHESDA PHARMACEUTICALS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1926487-A2 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS | University of Tennessee Research Foundation (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2008036067-A2 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2008-03-27 | — | — | WO | disclosed |
| WO-2003084940-A1 | THIAZOLIDINE-4-CARBONITRILES AND ANALOGUES AND THEIR USE AS DIPEPTIDYL-PEPTIDAS INHIBITORS | SANKARANARAYANAN ALANGUDI (IN) | 2003-10-16 | — | — | WO | disclosed |
| US-4243587-A | CYCLIZING A 3-ACYLAMINO-4A-ACETOXYAZETIDINONE ESTER WITH HYDROCHLORIC ACID TO OBTAIN THE 4-OXA-2,6-DIAZABICYCLO(3.2.0)HEPTANE | ELI LILLY AND COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| US-4226767-A | NOCARDICIN | ELI LILLY AND COMPANY (US) | 1980-10-07 | — | — | US | disclosed |
| US-4203896-A | WITH MERCURIC ACETATE AND ACETIC ACID, ACIDIC HYDROLYSIS OF N-PROPENYL GROUP | ELI LILLY AND COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| US-4180507-A | NOCARDICIN INTERMEDIATE | ELI LILLY AND COMPANY (US) | 1979-12-25 | — | — | US | disclosed |
| US-4158004-A | Process for antibiotic FR 1923 and related compounds | ELI LILLY AND COMPANY (US) | 1979-06-12 | — | — | US | disclosed |
| US-4144232-A | Substituted azetidin-2-one antibiotics | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |
| US-4127568-A | Process for 3β-aminoazetidin-2-ones | ELI LILLY AND COMPANY (US) | 1978-11-28 | — | — | US | disclosed |
| US-4075219-A | Epimerization process | ELI LILLY AND COMPANY (US) | 1978-02-21 | — | — | US | disclosed |