Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.40 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.40 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.40 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.40 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.40 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.40 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.40 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3548956 | 0.88 | IGF1R (0.45) | IDH1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL3555366 | 0.84 | IGF1R (0.41) | MAPK13MAPK12MAPK11MAPK14IDH1 | |
| SCHEMBL3551857 | 0.83 | MAPK13 (0.49) | BRD4JAK2JAK3MAPK13MAPK12 | |
| SCHEMBL3554499 | 0.79 | IGF1R (0.39) | MAPK13MAPK12MAPK11MAPK14IDH1 | |
| SCHEMBL3551540 | 0.78 | IDH1 (0.39) | MAPK13MAPK12MAPK11MAPK14IDH1 | |
| SCHEMBL3556828 | 0.77 | HDAC6 (0.38) | MAPK13MAPK12MAPK11MAPK14IDH1 | |
| SCHEMBL3552664 | 0.76 | HDAC6 (0.42) | MAPK13MAPK12MAPK11MAPK14IDH1 | |
| SCHEMBL3551701 | 0.76 | HDAC3 (0.39) | IDH1ATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL3553523 | 0.76 | PLK1 (0.44) | ATP1A1ATP1B1ATP1A3ATP1B2ATP1A2 | |
| SCHEMBL3551698 | 0.74 | HDAC3 (0.41) | MAPK14IDH1IGF1RNTRK1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | BRD4 38/4885JAK2 594/4885JAK3 291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.