Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 3/20 | 0.41 |
| ▸ | GCKR | Q14397 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29441491 | 0.98 | KMT2A (0.52) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| SCHEMBL177728 | 0.98 | KMT2A (0.52) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| Hydrochloric Acid SCHEMBL1865537 | 0.95 | KMT2A (0.50) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| Ammonia Solution, Strong SCHEMBL27669845 | 0.95 | KMT2A (0.50) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| Formic Acid SCHEMBL31490995 | 0.86 | KMT2A (0.51) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| Trifluoroacetic Acid SCHEMBL30699793 | 0.85 | KMT2A (0.54) | KMT2APTGS1ALDH1A1GCKGCKR | |
| SCHEMBL312533 | 0.81 | NPBWR1 (0.60) | NPBWR1PIK3CDKIF11GCKGCKR | |
| SCHEMBL9953539 | 0.80 | GCK (0.43) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| SCHEMBL11629001 | 0.80 | PIK3CD (0.42) | KMT2ANOS3NOS2BACE1NPBWR1 | |
| SCHEMBL29127263 | 0.80 | GCK (0.47) | KMT2ANOS3NOS2NPBWR1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795457-B2 | antitumor agents; anticancer agents; structurally related to the leptomycin family; Leptolstatin | KOSAN BIOSCIENCES INCORPORATED (US) | 2010-09-14 | — | — | US | disclosed |
| EP-2124927-A2 | CARBAMATE COMPOUNDS | Kosan Biosciences Incorporated (US) | 2009-12-02 | — | — | EP | disclosed |
| US-20080214617-A1 | Carbamate compounds | KOSAN BIOSCIENCES INCORPORATED | 2008-09-04 | — | — | US | disclosed |
| WO-2008106047-A2 | CARBAMATE COMPOUNDS | KOSAN BIOSCIENCES INCORPORATED (US) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214617-A1 | Carbamate compounds | CPS1, RB1, PRMT1 | KMT2A 610/4885NOS3 309/4885NOS2 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.