Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.62 |
| ▸ | CTSD | P07339 | 13/20 | 0.62 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12619151 | 0.81 | BACE1 (0.72) | BACE1CTSDBACE2 | |
| SCHEMBL2175749 | 0.80 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL3556417 | 0.79 | BACE1 (0.72) | BACE1CTSDBACE2 | |
| SCHEMBL15842005 | 0.77 | BACE1 (0.64) | BACE1CTSDBACE2 | |
| SCHEMBL15842006 | 0.77 | BACE1 (0.64) | BACE1CTSDBACE2 | |
| SCHEMBL15841556 | 0.77 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL15841557 | 0.77 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL12942655 | 0.76 | BACE1 (0.80) | BACE1CTSDBACE2 | |
| SCHEMBL8234264 | 0.76 | BACE1 (0.80) | BACE1CTSDBACE2 | |
| SCHEMBL15841681 | 0.76 | BACE1 (0.79) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |