Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.66 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | MELK | Q14680 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555085 | 0.87 | MAPK8 (0.66) | HDAC1HDAC6HDAC11HDAC8MAPK8 | |
| SCHEMBL1058355 | 0.86 | HDAC1 (0.66) | HDAC1MMP13SLC22A8HDAC6HDAC11 | |
| SCHEMBL6241073 | 0.86 | MMP13 (0.71) | HDAC1MMP13SLC22A8HDAC6HDAC11 | |
| SCHEMBL16668021 | 0.85 | HDAC1 (0.67) | HDAC1HDAC6HDAC11HDAC8HDAC3 | |
| SCHEMBL5070223 | 0.84 | HDAC1 (0.59) | HDAC1MMP13SLC22A8HDAC6HDAC11 | |
| SCHEMBL6509732 | 0.83 | MEN1 (0.60) | HDAC1MAPK8MAPK9TP53THRB | |
| SCHEMBL17241596 | 0.83 | TSHR (0.62) | HDAC1MAPK8MAPK9TNFTP53 | |
| SCHEMBL7095851 | 0.83 | MMP13 (0.65) | HDAC1MMP13SLC22A8HDAC6HDAC11 | |
| SCHEMBL6392927 | 0.83 | MMP13 (0.83) | HDAC1MMP13SLC22A8HDAC6HDAC11 | |
| SCHEMBL6247398 | 0.83 | MMP13 (0.64) | HDAC1MMP13SLC22A8HDAC6HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-20060058298-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2006-03-16 | — | — | US | disclosed |
| US-20050288282-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2005-12-29 | — | — | US | disclosed |
| US-6897220-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2005-05-24 | — | — | US | disclosed |
| US-20040142953-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2004-07-22 | — | — | US | disclosed |
| US-20040106599-A1 | Inhibitors of histone deacetylase | 92229129 QUEBEC INC. (CA) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288282-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885MMP13 449/4885SLC22A8 4653/4885 |
| US-20040106599-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885MMP13 449/4885SLC22A8 4653/4885 |
| US-20060058298-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885MMP13 449/4885SLC22A8 4653/4885 |
| US-20040142953-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885MMP13 449/4885SLC22A8 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.