Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Desloratadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.80 |
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.80 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.80 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.80 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.80 |
| ▸ | HRH2 | P25021 | 2/20 | 0.80 |
| ▸ | HTR2A | P28223 | 2/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.80 |
| ▸ | HTR2B | P41595 | 2/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.80 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.80 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desloratadine SCHEMBL3558046 | 0.95 | HRH1 (0.89) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL5200050 | 0.92 | HRH1 (0.83) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL4425 | 0.89 | HRH1 (1.00) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL29390260 | 0.89 | HRH1 (1.00) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL29371361 | 0.89 | HRH1 (1.00) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL4574215 | 0.88 | HRH1 (0.97) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL5198706 | 0.88 | HRH1 (0.97) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL5200429 | 0.88 | HRH1 (0.97) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL5200118 | 0.88 | HRH1 (0.97) | HRH1MEN1LMNACHRM2ABCB1 | |
| Desloratadine SCHEMBL5201486 | 0.88 | HRH1 (0.77) | HRH1MEN1LMNACHRM2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678908-B2 | Process of preparing desaloratadine | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2010-03-16 | — | — | US | disclosed |
| WO-2008050162-A1 | PROCESS FOR THE PREPARATION OF DESLORATADINE ADDUCT FORMED WITH CARBON DIOXIDE | EGIS GYÓGYSZERGYÁR Nyilvånosan Müködö Részvénytársaság (HU) | 2008-05-02 | — | — | WO | disclosed |
| US-7196195-B2 | Desloratadine salts, process for their synthesis and pharmaceutical compositions thereof | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2007-03-27 | — | — | US | disclosed |
| US-20060058334-A1 | Preperation of desloratine | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2006-03-16 | — | — | US | disclosed |
| EP-1347965-B1 | NEW DESLORATADINE SALTS, PROCESS FOR THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS THEREOF | RICHTER GEDEON VEGYESZET (HU) | 2006-01-25 | — | — | EP | disclosed |
| US-20050203116-A1 | Desloratadine salts,process for their synthesis and pharmaceutical compositions thereof | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2005-09-15 | — | — | US | disclosed |
| WO-2003086275-A2 | PREPERATION OF DESLORATATINE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2003-10-23 | — | — | WO | disclosed |
| EP-1347965-A1 | NEW DESLORATADINE SALTS, PROCESS FOR THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS THEREOF | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2003-10-01 | — | — | EP | disclosed |
| WO-2002042290-A1 | NEW DESLORATADINE SALTS, PROCESS FOR THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2002-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203116-A1 | Desloratadine salts,process for their synthesis and pharmaceutical compositions thereof | HRH2, CMA1, HRH1 | HRH1 3/4885MEN1 2136/4885LMNA 2223/4885 |
| US-20060058334-A1 | Preperation of desloratine | OPRM1, CHRM1, OPRL1 | HRH1 245/4885MEN1 3149/4885LMNA 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.