Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4398048 | 0.95 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL263877 | 0.95 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| Benzoic Acid SCHEMBL8538259 | 0.88 | TSHR (0.42) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL28863351 | 0.88 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| Benzoic Acid SCHEMBL8538257 | 0.88 | TSHR (0.42) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL28418300 | 0.83 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL9452987 | 0.83 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL23036792 | 0.80 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL15419478 | 0.80 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 | |
| SCHEMBL904626 | 0.80 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2GAAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368309-A2 | THIOL-MODIFIED HYALURONAN | Anika Therapeutics Inc. (US) | 2003-12-10 | — | — | EP | claimed |
| WO-2002068383-A2 | THIOL-MODIFIED HYALURONAN | ANIKA THERAPEUTICS, INC. (US) | 2002-09-06 | — | — | WO | claimed |
| EP-2597087-B1 | Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors | SHIONOGI & CO (JP) | 2016-03-30 | — | — | EP | disclosed |
| US-20150210680-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO (JP) | 2015-07-30 | — | — | US | disclosed |
| US-9029358-B2 | Aminodihydrothiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2015-05-12 | — | — | US | disclosed |
| EP-2612854-B1 | Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors | SHIONOGI & CO (JP) | 2015-04-29 | — | — | EP | disclosed |
| US-8895548-B2 | Pharmaceutical composition for treating alzheimer's disease | SHIONOGI & CO., LTD. (JP) | 2014-11-25 | — | — | US | disclosed |
| US-8815851-B2 | Aminodihydrothiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| EP-1942105-B1 | AMINODIHYDROTHIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2014-04-16 | — | — | EP | disclosed |
| US-20140058097-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE | SHIONOGI & CO., LTD. (JP) | 2014-02-27 | — | — | US | disclosed |
| US-8653067-B2 | Pharmaceutical composition for treating Alzheimer's disease | SHIONOGI & CO., LTD. (JP) | 2014-02-18 | — | — | US | disclosed |
| US-20130158260-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2013-06-20 | — | — | US | disclosed |
| EP-2597087-A1 | Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors | Shionogi&Co., Ltd. (JP) | 2013-05-29 | — | — | EP | disclosed |
| US-8173642-B2 | Aminodihydrothiazine derivatives | SHIONOGI & CO., LTD. (JP) | 2012-05-08 | — | — | US | disclosed |
| US-20120022249-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20120016116-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20100160290-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE | SHIONOGI & CO., LTD. (JP) | 2010-06-24 | — | — | US | disclosed |
| EP-2151435-A1 | PHARMACEUTICAL COMPOSITION FOR TREATMENT OF ALZHEIMER'S DISEASE | Shionogi&Co., Ltd. (JP) | 2010-02-10 | — | — | EP | disclosed |
| US-20090082560-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| EP-1942105-A1 | AMINODIHYDROTHIAZINE DERIVATIVE | Shionogi Co., Ltd. (JP) | 2008-07-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016116-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | ALDH1A1 1897/4885SMN1; SMN2 2228/4885GAA 1928/4885 |
| US-20100160290-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE | NR1H2, NR1H3, NR0B1 | ALDH1A1 2485/4885SMN1; SMN2 1376/4885GAA 2383/4885 |
| US-20130158260-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | ALDH1A1 1242/4885SMN1; SMN2 1042/4885GAA 930/4885 |
| US-20140058097-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING ALZHEIMER'S DISEASE | NR1H2, NR1H3, NR0B1 | ALDH1A1 2665/4885SMN1; SMN2 1359/4885GAA 2550/4885 |
| US-20120022249-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | ALDH1A1 1897/4885SMN1; SMN2 2228/4885GAA 1928/4885 |
| US-20150210680-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | ALDH1A1 1897/4885SMN1; SMN2 2228/4885GAA 1928/4885 |
| US-20090082560-A1 | AMINODIHYDROTHIAZINE DERIVATIVES | BACE1, BACE2, APP | ALDH1A1 1897/4885SMN1; SMN2 2228/4885GAA 1928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.