Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1358269 | 0.80 | CES2 (0.46) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL595614 | 0.79 | CES1 (0.50) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL1376581 | 0.77 | CES1 (0.48) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL20534688 | 0.77 | CES1 (0.48) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL891157 | 0.76 | TSHR (0.52) | CES1CES2AKR1B1TSHRALDH1A1 | |
| SCHEMBL43241 | 0.75 | CES1 (0.58) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL8778515 | 0.75 | CES2 (0.46) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL14274137 | 0.75 | CES1 (0.46) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL2313487 | 0.75 | CES1 (0.46) | CES1TP53CES2AKR1B1TSHR | |
| SCHEMBL28879808 | 0.75 | CES2 (0.46) | CES1TP53CES2AKR1B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838676-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-11-23 | — | — | US | disclosed |
| US-3968804-A | Extruded tobacco sheet | AMF INCORPORATED (US) | 1976-07-13 | — | — | US | disclosed |