SCHEMBL356027

SCHEMBL356027

C=C(C(=O)O)C1(O)CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10704155 0.87 CYP2C19 (0.33)
SCHEMBL9768346 0.81
SCHEMBL7630363 0.77
SCHEMBL23294925 0.75 EPHX1 (0.33)
SCHEMBL153693 0.67
SCHEMBL6757053 0.65
SCHEMBL23494104 0.64
SCHEMBL28875041 0.58 LDHA (0.33)
SCHEMBL66157 0.58
SCHEMBL2523687 0.58

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6991804-B2 Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia EDWARDS LIFESCIENCES CORPORATION (US) 2006-01-31 US claimed
US-20040202711-A1 Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia HELMUS MICHAEL N (US) 2004-10-14 US claimed
EP-0826082-B1 INTERNALLY-COATED POROUS WEBS WITH CONTROLLED POSITIONING OF MODIFIERS THEREIN NEXTEC APPLICATIONS INC (US) 2001-03-28 EP claimed
US-20220184181-A1 METHODS OF OCULAR TREATMENT USING AN ENGINEERED DIMERIC FRAGMENT OF HEPATOCYTE GROWTH FACTOR THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2022-06-16 US disclosed
US-20220033453-A1 HEPATOCYTE GROWTH FACTOR FRAGMENTS THAT FUNCTION AS POTENT MET RECEPTOR AGONISTS AND ANTAGONISTS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2022-02-03 US disclosed
US-20220023385-A1 ENGINEERED FIBROBLAST GROWTH FACTOR VARIANTS COMBINED WITH ENGINEERED HEPATOCYTE GROWTH FACTOR VARIANTS FOR TREATMENT THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS 2022-01-27 US disclosed
EP-3863660-A2 ENGINEERED FIBROBLAST GROWTH FACTOR VARIANTS AS RECEPTOR ANTAGONISTS The Board of Trustees of the Leland Stanford Junior University (US) 2021-08-18 EP disclosed
EP-3863715-A1 ENGINEERED FIBROBLAST GROWTH FACTOR VARIANTS COMBINED WITH ENGINEERED HEPATOCYTE GROWTH FACTOR VARIANTS FOR TREATMENT The Board of Trustees of the Leland Stanford Junior University (US) 2021-08-18 EP disclosed
US-20210100876-A1 Method of Treating of Fibroblast Growth Factor 21 (FGF-21) Deficiency 89BIO, INC. 2021-04-08 US disclosed
US-10874714-B2 Method of treating fibroblast growth factor 21 (FGF-21) deficiency 89BIO LTD. (IL) 2020-12-29 US disclosed
WO-2018018010-A1 FGF MUTANTS AND USES THEREOF METACRINE, INC. (US) 2018-01-25 WO disclosed
US-6083602-A SHEDDING SHIELD BARRIER WEB TREATED WITH CURABLE, SHEAR, THINNED, THIXOTROPIC POLYMER; WATERPROOF, DURABLE NEXTEC APPLICATIONS, INC. (US) 2000-07-04 US disclosed
EP-0826083-B1 BARRIER WEBS NEXTEC APPLICATIONS INC (US) 2000-04-05 EP disclosed
US-6040251-A Garments of barrier webs NEXTEC APPLICATIONS INC. (US) 2000-03-21 US disclosed
US-5912116-A BARRIER WEB OF CURABLE SHEAR THINNED THIXOTROPIC POLYMER NEXTEC APPLICATIONS, INC. (US) 1999-06-15 US disclosed
US-5874164-A BIOACTIVE SUBSTRATE COMPRISING SUPPORT WITH SURFACE COMPRISING PARTIALLY CURED SHEAR THINNABLE THIXOTROPIC POLYMER CONTAINING BIOACTIVE MATERIAL ORIENTED OUTWARD FROM SURFACE NEXTEC APPLICATIONS, INC. (US) 1999-02-23 US disclosed
US-5869172-A POROUS WEB TREATED WITH PARTIALLY CURED SHEAR THINNABLE THIXOTROPIC POLYMER AND MODIFIERS SELECTIVELY POSITIONED WITHIN WEB NEXTEC APPLICATIONS, INC. (US) 1999-02-09 US disclosed
US-5856245-A MEDICAL NEXTEC APPLICATIONS, INC. (US) 1999-01-05 US disclosed
EP-0826082-A2 INTERNALLY-COATED POROUS WEBS WITH CONTROLLED POSITIONING OF MODIFIERS THEREIN Nextec Applications, Inc. (US) 1998-03-04 EP disclosed
WO-1996036758-A2 INTERNALLY-COATED POROUS WEBS WITH CONTROLLED POSITIONING OF MODIFIERS THEREIN NEXTEC APPLICATIONS, INC. (US) 1996-11-21 WO disclosed