Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 14/20 | 0.58 |
| ▸ | CYP2C8 | P10632 | 14/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 14/20 | 0.58 |
| ▸ | CYP2B6 | P20813 | 14/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 14/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | BRS3 | P32247 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1065533 | 0.84 | HDAC1 (0.66) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL1065421 | 0.82 | CYP2E1 (0.83) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL15693611 | 0.79 | RAB9A (0.76) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL15693631 | 0.79 | CYP2E1 (0.82) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL1063187 | 0.77 | CYP2E1 (0.68) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL4650009 | 0.77 | CYP2E1 (0.81) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL15693621 | 0.76 | NPC1 (0.81) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL12195173 | 0.75 | CYP2E1 (0.82) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL13381572 | 0.75 | NPC1 (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL8347852 | 0.75 | RAB9A (0.61) | CYP2E1CYP2C8CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | claimed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-20060058298-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2006-03-16 | — | — | US | disclosed |
| US-20050288282-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2005-12-29 | — | — | US | disclosed |
| US-6897220-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2005-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288282-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | CYP2E1 4369/4885CYP2C8 4554/4885CYP2D6 4762/4885 |
| US-20060058298-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | CYP2E1 4369/4885CYP2C8 4554/4885CYP2D6 4762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.