Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KYAT1 | Q16773 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16361794 | 1.00 | MEN1 (0.65) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL3560755 | 1.00 | MEN1 (0.65) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL11767616 | 0.89 | KYAT1 (0.60) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL16730420 | 0.89 | KYAT1 (0.60) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL11767611 | 0.89 | KYAT1 (0.60) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL12266608 | 0.86 | MEN1 (0.64) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL12442232 | 0.86 | MAPT (0.59) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL10410691 | 0.86 | MAPT (0.59) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL19661582 | 0.86 | KYAT1 (0.62) | MEN1KMT2AKYAT1ALDH1A1LMNA | |
| SCHEMBL10410692 | 0.86 | MAPT (0.59) | MEN1KMT2AKYAT1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106543139-B | Triazolone compound and application thereof | 沈阳中化农药化工研发有限公司 | 2020-03-17 | — | — | CN | disclosed |
| CN-104395312-B | The Spirocyclic derivatives of 4,5-dihydro-pyrazolo [3,4-c] pyridin-2-ones, its preparation method and application | SICHUAN HAISCO PHARMACEUTICAL CO.,LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| CN-104395312-A | Substituted azabicycles and use thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2015-03-04 | — | — | CN | disclosed |
| WO-2014202027-A1 | SPIROCYCLIC DERIVATIVE OF 4,5-DIHYDROPYRAZOLO[3,4-C]PYRIDINE-2-ONE, PREPARATION METHOD AND USE THEREOF | 四川海思科制药有限公司 (CN) | 2014-12-24 | — | — | WO | disclosed |
| US-7745476-B2 | 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity | SOLVAY PHARMACEUTICALS B.V. (NL) | 2010-06-29 | — | — | US | disclosed |
| EP-1713475-B1 | 1,3,5-TRISUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY | SOLVAY PHARM BV (NL) | 2008-07-30 | — | — | EP | disclosed |
| EP-1713475-A1 | 1,3,5-TRISUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY | Solvay Pharmaceuticals B.V. (NL) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005074920-A1 | 1,3,5-TRISUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY | SOLVAY PHARMACEUTICALS B.V. (NL) | 2005-08-18 | — | — | WO | disclosed |
| US-20050171179-A1 | 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity | SOLVAY PHARMACEUTICALS B.V. | 2005-08-04 | — | — | US | disclosed |
| US-5091405-A | Insecticidal pyrazolines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-02-25 | — | — | US | disclosed |
| EP-0330678-B1 | INSECTICIDAL PYRAZOLINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-10-24 | — | — | EP | disclosed |
| EP-0330678-A1 | INSECTICIDAL PYRAZOLINES. | DU PONT (US) | 1989-09-06 | — | — | EP | disclosed |
| WO-1988006583-A1 | INSECTICIDAL PYRAZOLINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |
| US-4042706-A | Novel anti-inflammatory pyrazole derivatives and preparation thereof | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171179-A1 | 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity | CNR2, CNR1, TBXA2R | MEN1 2098/4885KMT2A 3150/4885KYAT1 2807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.