Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 18/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8278472 | 1.00 | SLC6A9 (0.50) | SLC6A9KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL761055 | 0.93 | SLC6A9 (0.58) | SLC6A9KDM4EHSD17B10 | |
| SCHEMBL760544 | 0.93 | SLC6A9 (0.58) | SLC6A9KDM4EHSD17B10 | |
| SCHEMBL3559226 | 0.76 | SLC6A9 (0.75) | SLC6A9 | |
| SCHEMBL3558640 | 0.75 | KDM4E (0.50) | SLC6A9KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL3557643 | 0.73 | SLC6A9 (0.67) | SLC6A9 | |
| SCHEMBL3565781 | 0.73 | SLC6A9 (0.67) | SLC6A9 | |
| SCHEMBL3561972 | 0.73 | KDM4E (0.56) | SLC6A9KDM4EHSD17B10 | |
| SCHEMBL3560558 | 0.73 | SLC6A9 (0.68) | SLC6A9 | |
| SCHEMBL3562067 | 0.73 | SLC6A9 (0.90) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729772-B1 | HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK SHARP & DOHME (US) | 2016-12-07 | — | — | EP | disclosed |
| US-7825135-B2 | Heteroaryl piperidine glycine transporter inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2010-11-02 | — | — | US | disclosed |
| US-20070254880-A1 | Heteroaryl Piperidine Glycine Transporter Inhibitors | MERCK SHARP & DOHME LLC | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254880-A1 | Heteroaryl Piperidine Glycine Transporter Inhibitors | SLC1A2, SLC1A1, SLC1A3 | SLC6A9 33/4885KDM4E 3789/4885ALDH1A1 1871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.