Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.56 |
| ▸ | KDR | P35968 | 18/20 | 0.56 |
| ▸ | IGF1R | P08069 | 15/20 | 0.56 |
| ▸ | MST1R | Q04912 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198531 | 0.93 | KDR (0.58) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL200162 | 0.93 | MET (0.58) | METKDRIGF1RMST1RINSR | |
| SCHEMBL197608 | 0.93 | KDR (0.58) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL200732 | 0.92 | MET (0.56) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL199596 | 0.91 | MET (0.53) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL199595 | 0.91 | MET (0.53) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL14003861 | 0.85 | KDR (0.53) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL2742559 | 0.84 | MET (0.61) | METKDRIGF1RMST1RAURKA | |
| SCHEMBL198021 | 0.84 | KDR (0.59) | METKDRIGF1RMST1R | |
| SCHEMBL200073 | 0.83 | MET (0.66) | METKDRIGF1RMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858623-B2 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2010-12-28 | — | — | US | claimed |