Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | TXK | P42681 | 1/20 | 0.46 |
| ▸ | BLK | P51451 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29440654 | 0.87 | POLB (0.58) | POLBBTKMEN1KMT2ARAB9A | |
| SCHEMBL23525602 | 0.87 | POLB (0.58) | POLBBTKMEN1KMT2ARAB9A | |
| SCHEMBL29025387 | 0.82 | POLB (0.56) | POLBBTKMEN1KMT2ARAB9A | |
| SCHEMBL12822399 | 0.81 | FGFR1 (0.50) | POLB | |
| SCHEMBL29436997 | 0.80 | POLB (0.64) | POLBBTKMEN1KMT2ARAB9A | |
| SCHEMBL19409427 | 0.80 | POLB (0.64) | POLBBTKMEN1KMT2ARAB9A | |
| SCHEMBL16586798 | 0.76 | POLB (0.67) | POLBMEN1KMT2ARAB9AGAA | |
| SCHEMBL6753728 | 0.76 | POLB (0.62) | POLBBTKMEN1KMT2ARAB9A | |
| SCHEMBL10972297 | 0.74 | KMT2A (0.74) | POLBMEN1KMT2ARAB9AGAA | |
| SCHEMBL16337213 | 0.74 | BTK (1.00) | BTKJAK2NTRK1LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696215-B2 | 4-oxoquinazolin-3-yl benzamide derivatives for the treatment of cytokine diseases | ASTRAZENECA AB (SE) | 2010-04-13 | — | — | US | disclosed |