Sugi Predict

Sugi Predict / Compounds / SCHEMBL3564430

SCHEMBL3564430

SCHEMBL3564430

COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cc(F)c(NCc4ccncc4)c(C(=O)N(C)C)c3)cc12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAP4K1 Q92918 1/20 0.39
▸ PTPN11 Q06124 1/20 0.37
▸ ABL1 P00519 2/20 0.37
▸ NAMPT P43490 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ TP53 P04637 1/20 0.35
▸ PDE5A O76074 1/20 0.34
▸ EGFR P00533 1/20 0.34
▸ TRIM24 O15164 1/20 0.34
▸ TRIM33 Q9UPN9 1/20 0.34
▸ EED O75530 1/20 0.34
▸ PDPK1 O15530 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ PI4KB Q9UBF8 1/20 0.33
▸ CNR2 P34972 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ GPBAR1 Q8TDU6 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13816796 0.87 MAP4K1 (0.40) MAP4K1PTPN11ABL1LMNAMAPT
SCHEMBL3566926 0.86 MAP4K1 (0.45) MAP4K1PTPN11ABL1LMNAMAPT
SCHEMBL3563287 0.86 PTPN11 (0.43) MAP4K1PTPN11ABL1LMNATP53
SCHEMBL3565214 0.86 MAP4K1 (0.40) MAP4K1PTPN11ABL1LMNAEED
SCHEMBL3562857 0.85 MAP4K1 (0.39) MAP4K1PTPN11ABL1LMNAEED
SCHEMBL3566923 0.83 MAP4K1 (0.42) MAP4K1PTPN11ABL1LMNAEED
SCHEMBL3573801 0.82 PTPN11 (0.40) MAP4K1PTPN11ABL1LMNATP53
SCHEMBL1516677 0.81 PTPN11 (0.43) MAP4K1PTPN11ABL1LMNATRIM24
SCHEMBL3562904 0.81 PIK3CA (0.39) MAP4K1PTPN11ABL1LMNA
SCHEMBL14208401 0.80 PTPN11 (0.42) MAP4K1PTPN11ABL1EEDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7709645-B2 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2010-05-04 — — US disclosed
US-7709645-B2 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2010-05-04 — — US disclosed
US-7709645-B2 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2010-05-04 — — US disclosed
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS SGX PHARMACEUTICALS, INC. (US) 2009-06-04 — — US disclosed
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS SGX PHARMACEUTICALS, INC. (US) 2009-06-04 — — US disclosed
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS SGX PHARMACEUTICALS, INC. (US) 2009-06-04 — — US disclosed
WO-2008124849-A2 PYRROLO-PYRIDINE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2008-10-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS MAP4K2, PDXK, MAP4K1 MAP4K1 3/4885PTPN11 1303/4885ABL1 348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.