Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | STAT3 | P40763 | 4/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | GSK3B | P49841 | 3/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | LATS1 | O95835 | 3/20 | 0.30 |
| ▸ | LATS2 | Q9NRM7 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL3574027 | 0.83 | JAK2 (0.42) | JAK2STAT3JAK1TYK2JAK3 | |
| Pyridine SCHEMBL3562760 | 0.82 | JAK2 (0.44) | JAK2STAT3JAK1TYK2JAK3 | |
| Pyridine SCHEMBL3571503 | 0.82 | CTSK (0.43) | JAK2STAT3JAK1TYK2JAK3 | |
| Pyridine SCHEMBL5622345 | 0.81 | MAPK1 (0.34) | MAPK1GBA1TAS1R3TAS1R1LATS1 | |
| Pyridine SCHEMBL3569024 | 0.76 | MEN1 (0.38) | GSK3BGBA1 | |
| Pyridine SCHEMBL3572010 | 0.71 | JAK2 (0.33) | JAK2STAT3JAK1TYK2JAK3 | |
| SCHEMBL3566014 | 0.71 | SYK (0.32) | SYKMAPK1TAS1R3TAS1R1 | |
| Pyridine SCHEMBL3573055 | 0.69 | TYRO3 (0.37) | JAK2STAT3JAK1TYK2JAK3 | |
| Pyridine SCHEMBL3569208 | 0.69 | MAPT (0.37) | — | |
| SCHEMBL7357712 | 0.68 | GAA (0.47) | JAK2MAPK1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855212-B2 | Pyridinyl acetonitriles | MERCK SERONO SA (CH) | 2010-12-21 | — | — | US | claimed |
| US-20070060594-A1 | Pyridinyl acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-03-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060594-A1 | Pyridinyl acetonitriles | GSK3B, GSK3A, MAPK3 | JAK2 432/4885STAT3 638/4885JAK1 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.