Sugi Predict

Sugi Predict / Compounds / SCHEMBL3566969

SCHEMBL3566969

SCHEMBL3566969

COc1ccccc1-c1cn(S(=O)(=O)c2ccc(C)cc2)c2ncc(-c3cc(C(=O)N(C)C)c(N)nn3)cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.44
▸ TSHR P16473 2/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ MAP4K1 Q92918 1/20 0.42
▸ PTPN11 Q06124 1/20 0.41
▸ KMT2A Q03164 5/20 0.39
▸ ALDH1A1 P00352 4/20 0.39
▸ MEN1 O00255 3/20 0.39
▸ HTT P42858 2/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ ABL1 P00519 2/20 0.38
▸ LMNA P02545 3/20 0.37
▸ MAPK1 P28482 2/20 0.37
▸ HSD17B10 Q99714 1/20 0.34
▸ POLB P06746 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ BRD4 O60885 1/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ CCNE2 O96020 1/20 0.33
▸ CCNE1 P24864 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3565148 0.86 MAP4K1 (0.59) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL3566926 0.84 MAP4K1 (0.45) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL3565147 0.84 MAP4K1 (0.48) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL3572307 0.84 PTPN11 (0.42) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL3563287 0.83 PTPN11 (0.43) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL14208401 0.82 PTPN11 (0.42) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL3566923 0.82 MAP4K1 (0.42) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL3568986 0.80 MAP4K1 (0.44) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL5060832 0.80 PTPN11 (0.41) MAPTTSHRSMN1; SMN2MAP4K1PTPN11
SCHEMBL13342637 0.79 PTPN11 (0.51) MAPTTSHRSMN1; SMN2MAP4K1PTPN11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7709645-B2 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2010-05-04 — — US disclosed
US-7709645-B2 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2010-05-04 — — US disclosed
US-7709645-B2 Pyrrolo-pyridine kinase modulators SGX PHARMACEUTICALS, INC. (US) 2010-05-04 — — US disclosed
EP-2134343-A2 PYRROLO-PYRIDINE KINASE MODULATORS SGX Pharmaceuticals, Inc. (US) 2009-12-23 — — EP disclosed
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS SGX PHARMACEUTICALS, INC. (US) 2009-06-04 — — US disclosed
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS SGX PHARMACEUTICALS, INC. (US) 2009-06-04 — — US disclosed
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS SGX PHARMACEUTICALS, INC. (US) 2009-06-04 — — US disclosed
WO-2008124849-A2 PYRROLO-PYRIDINE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2008-10-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143352-A1 PYRROLO-PYRIDINE KINASE MODULATIORS MAP4K2, PDXK, MAP4K1 MAPT 1385/4885TSHR 3000/4885SMN1; SMN2 2843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.