Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | CRHBP | P24387 | 2/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578793 | 1.00 | HDAC1 (0.76) | HDAC1HDAC3HDAC8HDAC2NCOR2 | |
| SCHEMBL1883963 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL1887639 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL1892719 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL3573802 | 0.86 | HDAC1 (0.55) | HDAC1HDAC3HDAC8HDAC2 | |
| SCHEMBL3571918 | 0.84 | HDAC1 (0.54) | HDAC1HDAC3HDAC8HDAC2NCOR2 | |
| SCHEMBL3576079 | 0.84 | HDAC1 (0.54) | HDAC1HDAC3HDAC8HDAC2NCOR2 | |
| SCHEMBL3573257 | 0.83 | HDAC1 (0.52) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL3570949 | 0.83 | HDAC1 (0.52) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL3572285 | 0.83 | HDAC1 (0.52) | HDAC1HDAC3HDAC8HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082308-A1 | Benzothiophene derivatives | MERCK SHARP & DOHME LLC | 2009-03-26 | — | — | US | claimed |
| US-7834034-B2 | Benzothiophene derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090082308-A1 | Benzothiophene derivatives | MERCK SHARP & DOHME LLC | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082308-A1 | Benzothiophene derivatives | BRDT, HDAC5, BRPF3 | HDAC1 4/4885HDAC3 10/4885HDAC8 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.