Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572285 | 1.00 | HDAC1 (0.52) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL3573257 | 0.94 | HDAC1 (0.52) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL3573802 | 0.87 | HDAC1 (0.55) | HDAC1HDAC2HDAC3HDAC8 | |
| SCHEMBL3578793 | 0.83 | HDAC1 (0.76) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL3568924 | 0.83 | HDAC1 (0.76) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL4459748 | 0.80 | HDAC1 (0.68) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL1001467 | 0.80 | HDAC1 (0.68) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL1689224 | 0.80 | HDAC1 (0.61) | HDAC1HDAC2HDAC3 | |
| SCHEMBL3565990 | 0.80 | HDAC1 (0.50) | HDAC1HDAC2HDAC3HDAC8HDAC10 | |
| SCHEMBL3566830 | 0.78 | HDAC1 (0.51) | HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090082308-A1 | Benzothiophene derivatives | MERCK SHARP & DOHME LLC | 2009-03-26 | — | — | US | claimed |
| US-7834034-B2 | Benzothiophene derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090082308-A1 | Benzothiophene derivatives | MERCK SHARP & DOHME LLC | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082308-A1 | Benzothiophene derivatives | BRDT, HDAC5, BRPF3 | HDAC1 4/4885HDAC2 8/4885HDAC3 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.