⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL421623 | 0.82 | CRBN (0.32) | — | |
| SCHEMBL1816977 | 0.72 | — | — | |
| SCHEMBL3801338 | 0.72 | — | — | |
| SCHEMBL182774 | 0.69 | — | — | |
| SCHEMBL383561 | 0.68 | — | — | |
| SCHEMBL1150564 | 0.68 | — | — | |
| SCHEMBL33371399 | 0.68 | CRBN (0.33) | — | |
| SCHEMBL68773 | 0.68 | CRBN (0.33) | — | |
| SCHEMBL1600759 | 0.68 | CRBN (0.30) | — | |
| Benzamide SCHEMBL28297315 | 0.67 | POLB (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330102-A1 | PROTAC ANTIBODY CONJUGATES AND METHODS OF USE | GENENTECH, INC. | 2023-10-19 | — | — | US | disclosed |
| US-11666581-B2 | PROTAC antibody conjugates and methods of use | GENENTECH, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-20230126271-A1 | DEGRADER-ANTIBODY CONJUGATES AND METHODS OF USING SAME | ANGIEX, INC. | 2023-04-27 | — | — | US | disclosed |
| WO-2023056069-A1 | DEGRADER-ANTIBODY CONJUGATES AND METHODS OF USING SAME | ANGIEX, INC. (US) | 2023-04-06 | — | — | WO | disclosed |
| CN-115734789-A | Degradant-antibody conjugates and methods of use thereof | 安吉克公司 | 2023-03-03 | — | — | CN | disclosed |
| EP-4126042-A2 | DEGRADER-ANTIBODY CONJUGATES AND METHODS OF USING SAME | Angiex, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021195598-A2 | DEGRADER-ANTIBODY CONJUGATES AND METHODS OF USING SAME | ANGIEX, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| US-20190175612-A1 | PROTAC ANTIBODY CONJUGATES AND METHODS OF USE | GENENTECH, INC. | 2019-06-13 | — | — | US | disclosed |
| EP-3458101-A1 | PROTAC ANTIBODY CONJUGATES AND METHODS OF USE | H. Hoffnabb-La Roche Ag (CH) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017201449-A1 | PROTAC ANTIBODY CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
| US-4033751-A | 2-(Substituted-phenyl)-hexahydro- and tetrahydro-3-(2H)-cinnolinones as herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-07-05 | — | — | US | disclosed |
| US-4033751-A | 2-(Substituted-phenyl)-hexahydro- and tetrahydro-3-(2H)-cinnolinones as herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-07-05 | — | — | US | disclosed |
| US-4033751-A | 2-(Substituted-phenyl)-hexahydro- and tetrahydro-3-(2H)-cinnolinones as herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-07-05 | — | — | US | disclosed |