Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.42 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156518 | 0.92 | PLK1 (0.42) | PLK1PLK3CYP3A4CYP2C9NEK2 | |
| SCHEMBL5003591 | 0.89 | AKR1C3 (0.43) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL3577059 | 0.86 | PLK1 (0.40) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL3577258 | 0.86 | PLK1 (0.38) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL3577255 | 0.86 | PLK1 (0.38) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL14047869 | 0.85 | PLK1 (0.34) | PLK1PLK3CYP3A4CYP2C9NEK2 | |
| SCHEMBL4632899 | 0.82 | PLK1 (0.35) | PLK1PLK3CYP3A4CYP2C9NEK2 | |
| SCHEMBL4395211 | 0.81 | PLK1 (0.41) | PLK1PLK3CYP3A4CYP2C9NEK2 | |
| SCHEMBL4778390 | 0.79 | PLK1 (0.38) | PLK1PLK3CYP3A4CYP2C9NEK2 | |
| SCHEMBL3148252 | 0.79 | PLK1 (0.38) | PLK1PLK3CYP3A4CYP2C9NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056525-A1 | 5- AND 6- SUBSTITUTED BENZIMIDAZOLE THIOPHENE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2010-03-04 | — | — | US | disclosed |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | SMITHKLINE BEECHAM CORPORATION | 2008-10-09 | — | — | US | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056525-A1 | 5- AND 6- SUBSTITUTED BENZIMIDAZOLE THIOPHENE COMPOUNDS | CYP3A5, CYP2B6, CYP3A4 | PLK1 836/4885PLK3 1941/4885CYP3A4 3/4885 |
| US-20080249301-A1 | Regioselective Process for Preparing Benzimidazole Thiophenes | CYP3A4, CYP2C19, CYP2B6 | PLK1 1718/4885PLK3 2097/4885CYP3A4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.