Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 13/20 | 0.35 |
| ▸ | NEK2 | P51955 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569266 | 0.82 | PLK1 (0.42) | PLK1NEK2CYP3A4CYP2C9PLK3 | |
| SCHEMBL3156518 | 0.77 | PLK1 (0.42) | PLK1NEK2CYP3A4CYP2C9PLK3 | |
| SCHEMBL4632897 | 0.75 | NEK2 (0.40) | PLK1NEK2CYP3A4CYP2C9PLK3 | |
| SCHEMBL14047869 | 0.73 | PLK1 (0.34) | PLK1NEK2CYP3A4CYP2C9PLK3 | |
| SCHEMBL5003591 | 0.71 | AKR1C3 (0.43) | PLK1CYP3A4CYP2C9PLK3AKR1C3 | |
| SCHEMBL3577258 | 0.69 | PLK1 (0.38) | PLK1CYP3A4CYP2C9PLK3AKR1C3 | |
| SCHEMBL3577255 | 0.69 | PLK1 (0.38) | PLK1CYP3A4CYP2C9PLK3AKR1C3 | |
| SCHEMBL4632896 | 0.69 | AAK1 (0.33) | PLK1NEK2AKR1C3AKR1C2AAK1 | |
| SCHEMBL2991160 | 0.69 | PLK1 (0.50) | PLK1NEK2CYP3A4CYP2C9PLK3 | |
| SCHEMBL3577059 | 0.69 | PLK1 (0.40) | PLK1CYP3A4CYP2C9PLK3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |