Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HTR2B | P41595 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4656255 | 0.89 | MEN1 (0.47) | MEN1KMT2AHTR2BTP53MAPT | |
| SCHEMBL925357 | 0.82 | HTR2B (0.57) | MEN1KMT2AHTR2BTP53MAPT | |
| SCHEMBL3569668 | 0.79 | KDM4E (0.53) | MEN1KMT2AHTR2BTP53MAPT | |
| SCHEMBL4599683 | 0.79 | IDO1 (0.50) | MEN1KMT2AKDM4ETDP1IDO1 | |
| SCHEMBL2811261 | 0.77 | HTR2B (0.47) | MEN1KMT2AHTR2BTP53MAPT | |
| SCHEMBL925236 | 0.76 | HTR2B (0.47) | MEN1KMT2AHTR2BTP53MAPT | |
| SCHEMBL3566596 | 0.74 | IDO1 (0.48) | MEN1KMT2ATP53MAPTKDM4E | |
| SCHEMBL926859 | 0.74 | GRM4 (0.49) | MEN1KMT2AHTR2BTP53MAPT | |
| SCHEMBL15361984 | 0.74 | MAOB (0.48) | MEN1KMT2AHTR2BTP53MAPT | |
| Hydrochloric Acid SCHEMBL3576467 | 0.73 | MAOB (0.47) | MEN1KMT2AHTR2BTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735432-B2 | N-(Heteroaryl)-1-heteroarylalky1-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| EP-1910335-B1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2013-11-06 | — | — | EP | disclosed |
| US-20130046095-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | DUBOIS LAURENT (FR) | 2013-02-21 | — | — | US | disclosed |
| US-8318775-B2 | N-(heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2012-11-27 | — | — | US | disclosed |
| US-20100222368-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-09-02 | — | — | US | disclosed |
| US-7745467-B2 | N-(heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-06-29 | — | — | US | disclosed |
| US-20080146646-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222368-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | IDO1, IDO2, CNR2 | MEN1 2056/4885KMT2A 1418/4885HTR2B 40/4885 |
| US-20130046095-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | IDO1, IDO2, CNR2 | MEN1 2056/4885KMT2A 1418/4885HTR2B 40/4885 |
| US-20080146646-A1 | N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof | IDO1, IDO2, CNR2 | MEN1 2056/4885KMT2A 1418/4885HTR2B 40/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.