Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3569671 | 0.89 | MEN1 (0.53) | MEN1KMT2AMAOBNOTUMHTR2B | |
| SCHEMBL2811261 | 0.81 | HTR2B (0.47) | MEN1KMT2AMAOBNOTUMHTR2B | |
| SCHEMBL4657644 | 0.80 | ECE1 (0.52) | NOTUMPTGDR2ECE1 | |
| SCHEMBL4656256 | 0.79 | ECE1 (0.62) | NOTUMALDH1A1PTGDR2TSHRECE1 | |
| SCHEMBL4656147 | 0.77 | ECE1 (0.55) | NOTUMALDH1A1PTGDR2TSHRECE1 | |
| SCHEMBL4656319 | 0.77 | ECE1 (0.50) | MEN1KMT2AMAOBNOTUMHTR2B | |
| SCHEMBL4655406 | 0.77 | ECE1 (0.54) | MEN1KMT2AMAOBNOTUMHTR2B | |
| SCHEMBL926859 | 0.76 | GRM4 (0.49) | MEN1KMT2AMAOBNOTUMHTR2B | |
| SCHEMBL4655323 | 0.76 | ECE1 (0.63) | ECE1 | |
| SCHEMBL4655399 | 0.76 | ECE1 (0.53) | PTGDR2ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101010297-B | N- (1H-indolyl) -1H-indole-2-carboxamide derivatives, their preparation and their pharmaceutical use | SANOFI AVENTIS | 2011-07-27 | — | — | CN | claimed |
| EP-1776340-B1 | N-(1H-INDOLYL)-H-INDOLE-2-CARB0XAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2008-12-03 | — | — | EP | claimed |