Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL199306 | 0.86 | ALDH1A1 (0.65) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL31519065 | 0.84 | ALDH1A1 (0.63) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL28812535 | 0.84 | ALDH1A1 (0.63) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL31653378 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL4289 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL31517328 | 0.77 | ALDH1A1 (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL13473987 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL30261053 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL13822150 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 | |
| SCHEMBL28030385 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1NPC1MAPK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078721-B1 | Thieno-pyrimidine compounds having fungicidal activity | DOW AGROSCIENCES LLC (US) | 2014-01-22 | — | — | EP | disclosed |
| US-20100035934-A1 | PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S | 2010-02-11 | — | — | US | disclosed |
| EP-2114916-A2 | PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NeuroSearch A/S (DK) | 2009-11-11 | — | — | EP | disclosed |
| EP-2078721-A2 | Thieno-pyrimidime compounds having fungicidal activity | Dow AgroSciences LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| US-7531482-B2 | Thieno-pyrimidine compounds having fungicidal activity | DOW AGROSCIENCES LLC (US) | 2009-05-12 | — | — | US | disclosed |
| WO-2008092942-A2 | PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-08-07 | — | — | WO | disclosed |
| EP-1937691-A1 | THIENO-PYRIMIDINE COMPOUNDS HAVING FUNGICIDAL ACTIVITY | Dow Agrosciences LLC (US) | 2008-07-02 | — | — | EP | disclosed |
| US-20070093498-A1 | Thieno-pyrimidine compounds having fungicidal activity | BREWSTER WILLIAM K | 2007-04-26 | — | — | US | disclosed |
| WO-2007046809-A1 | THIENO-PYRIMIDINE COMPOUNDS HAVING FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093498-A1 | Thieno-pyrimidine compounds having fungicidal activity | TYMP, DPM1, TYMS | KDM4E 1522/4885ALDH1A1 539/4885NPC1 3134/4885 |
| US-20100035934-A1 | PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNJ2, KCNA3, KCNQ1 | KDM4E 1098/4885ALDH1A1 3006/4885NPC1 960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.