Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | CDK14 | O94921 | 2/20 | 0.32 |
| ▸ | CCNY | Q8ND76 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3570797 | 1.00 | SYK (0.35) | SYKL3MBTL1WEE1CDK14CCNY | |
| SCHEMBL3570580 | 0.93 | SYK (0.37) | SYKL3MBTL1WEE1KDM4EALDH1A1 | |
| SCHEMBL3570584 | 0.93 | SYK (0.37) | SYKL3MBTL1WEE1KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3568696 | 0.90 | KDM4E (0.33) | L3MBTL1CDK14CCNYKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3568698 | 0.90 | KDM4E (0.33) | L3MBTL1CDK14CCNYKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3566373 | 0.90 | PDK2 (0.40) | SYKCDK14CCNYKDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL3566369 | 0.90 | PDK2 (0.40) | SYKCDK14CCNYKDM4EALDH1A1 | |
| SCHEMBL13344140 | 0.88 | SYK (0.36) | SYKL3MBTL1KDM4EALDH1A1MEN1 | |
| Trifluoroacetic Acid SCHEMBL3572477 | 0.87 | CDK14 (0.38) | SYKL3MBTL1CDK14CCNYKDM4E | |
| Trifluoroacetic Acid SCHEMBL3572482 | 0.87 | CDK14 (0.38) | SYKL3MBTL1CDK14CCNYKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | SULT1E1, RECQL, HAX1 | SYK 3389/4885L3MBTL1 838/4885WEE1 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.