Sugi Predict
/ Targets
/ HAX1
Top predicted compounds (top 20 by supporting neighbours, then confidence)
Clinical trials — most relevant to HAX1 by text similarity (a relevance ranking, not an exhaustive list)
| Trial | Phase | Status |
|---|
| LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery |
PHASE4 | COMPLETED |
| TOP: Recombinant Human Parathyroid Hormone (ALX1-11) on Fracture Incidence in Women With Postmenopausal Osteoporosis |
PHASE3 | COMPLETED |
| A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia |
PHASE3 | COMPLETED |
| A Study to Evaluate the Efficacy and Safety of HLX14 vs. Denosumab Prolia® in Postmenopausal Women With Osteoporosis at High Risk of Fracture |
PHASE3 | COMPLETED |
| A Global Phase II/III Clinical Study to Evaluate the Efficacy and Safety of HLX43 Monotherapy or HLX43 in Combination With HLX07 Versus Docetaxel in Advanced or Metastatic Squamous Non-Small Cell Lung Cancer |
PHASE2/PHASE3 | RECRUITING |
| A Study to Assess the Safety and Efficacy of 3 Doses of ALX1-11 (50, 75, and 100µg) in the Treatment of Postmenopausal Osteoporosis |
PHASE2 | COMPLETED |
| A Phase II Clinical Study to Evaluate HLX43 in Patients With Locally Advanced or Metastatic HCC Failed or Intolerance to Standard Therapy |
PHASE2 | RECRUITING |
| A Phase II Clinical Study to Evaluate HLX43 in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC) |
PHASE2 | RECRUITING |
| A Phase II Clinical Study to Evaluate HLX43 in Subjects With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma |
PHASE2 | RECRUITING |
| A Phase Ib/II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Patients With Advanced/Metastatic Solid Tumors |
PHASE1/PHASE2 | RECRUITING |
| A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome |
PHASE2 | RECRUITING |
| Gene Therapy for X-linked Severe Combined Immunodeficiency |
PHASE1/PHASE2 | COMPLETED |
| Phase II, Open-label, Multicenter Study to Evaluate the Efficacy and Safety of HLX43 (an Anti-PD-L1 ADC) in Subjects With Advanced Colorectal Cancer |
PHASE2 | RECRUITING |
| A Phase II Study to Evaluate the Efficacy and Safety of HLX43 + Serplulimab as Neoadjuvant Therapy in Subjects With NSCLC |
PHASE2 | RECRUITING |
| A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of HLX35 in Combination With HLX10 in Patients With Advanced or Metastatic Solid Tumors |
PHASE1 | UNKNOWN |
| A Study of HLX42 in Advanced/Metastatic Solid Tumors |
PHASE1 | RECRUITING |
| A Phase I Study to Evaluate the Safety, Tolerability, and PK of HLX43 in Advanced/Metastatic Solid Tumors |
PHASE1 | ENROLLING_BY_INVITATION |
| A Clinical Trial to Assess PVX7 Immunotherapy Regimens in Advanced Cervical Cancer Patients |
PHASE1 | RECRUITING |
| Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners |
nan | ACTIVE_NOT_RECRUITING |
| Proteomics of Primary Hyperoxaluria Type 1 |
nan | COMPLETED |
| Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing |
nan | RECRUITING |
| Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing |
nan | RECRUITING |
| X-chromosome Inactivation, Epigenetics and the Transcriptome |
nan | COMPLETED |
| Rare Kidney Stone Consortium Biobank |
nan | RECRUITING |
| Use of miRNAs in Growth Hormone Deficiency (GHD) |
nan | UNKNOWN |
| Clinical Evaluation of Patients With X-linked Retinoschisis |
nan | COMPLETED |
| Study of Genetic and Molecular Defects in Primary Immunodeficiency Disorders |
nan | UNKNOWN |
| Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1) |
nan | UNKNOWN |
| Stone Disease in Children and Their Families |
nan | COMPLETED |
| Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis. |
nan | COMPLETED |
Related proteins — ESM-2 sequence neighbours (a HAX1 binder may also engage these)