Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | IGF1R | P08069 | 11/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572322 | 0.88 | MAP4K1 (0.68) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342422 | 0.87 | MAP4K1 (0.63) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342306 | 0.87 | MAP4K1 (0.71) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342355 | 0.84 | MAP4K1 (0.73) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342430 | 0.83 | MAP4K1 (0.61) | MAP4K1ABL1IGF1RKIT | |
| SCHEMBL13342354 | 0.83 | MAP4K1 (0.76) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342358 | 0.83 | MAP4K1 (0.76) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342215 | 0.83 | MAP4K1 (0.67) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342677 | 0.82 | MAP4K1 (0.69) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 | |
| SCHEMBL13342308 | 0.82 | MAP4K1 (0.71) | MAP4K1ABL1IGF1RCYP3A4CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709645-B2 | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709645-B2 | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709645-B2 | Pyrrolo-pyridine kinase modulators | SGX PHARMACEUTICALS, INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20090143352-A1 | PYRROLO-PYRIDINE KINASE MODULATIORS | SGX PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143352-A1 | PYRROLO-PYRIDINE KINASE MODULATIORS | SGX PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143352-A1 | PYRROLO-PYRIDINE KINASE MODULATIORS | SGX PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| WO-2008124849-A2 | PYRROLO-PYRIDINE KINASE MODULATORS | SGX PHARMACEUTICALS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143352-A1 | PYRROLO-PYRIDINE KINASE MODULATIORS | MAP4K2, PDXK, MAP4K1 | MAP4K1 3/4885ABL1 348/4885IGF1R 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.