Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26667262 | 0.73 | CA1 (0.42) | CA1CA2CA7CA9 | |
| SCHEMBL3241686 | 0.71 | — | — | |
| SCHEMBL3570194 | 0.71 | — | — | |
| SCHEMBL15054412 | 0.70 | CA1 (0.40) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL22405499 | 0.70 | CA1 (0.40) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL22406008 | 0.70 | CA1 (0.40) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL2175005 | 0.68 | — | — | |
| SCHEMBL2175003 | 0.68 | ALDH1A1 (0.34) | ALDH1A1CA1CA2CA7 | |
| SCHEMBL4436363 | 0.67 | CPA1 (0.38) | ALDH1A1 | |
| SCHEMBL4436371 | 0.67 | CPA1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745484-B2 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070185144-A1 | Beta-secretase modulators and methods of use | AMGEN INC. (US) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185144-A1 | Beta-secretase modulators and methods of use | BACE1, BACE2, APP | ALDH1A1 2461/4885CA1 290/4885CA2 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.