Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | GFER | P55789 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28087528 | 0.82 | HTR2A (0.41) | MAPTGAAMCHR1SMN1; SMN2SIGMAR1 | |
| SCHEMBL3567979 | 0.80 | MAPT (0.49) | MAPTGFERKDM4EGAAALDH1A1 | |
| SCHEMBL3566234 | 0.80 | MCHR1 (0.60) | MCHR1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL21758052 | 0.76 | MAPT (0.45) | MAPTGFERKDM4EGAAALDH1A1 | |
| SCHEMBL1409679 | 0.75 | MAPT (0.53) | MAPTGFERKDM4EGAAALDH1A1 | |
| SCHEMBL3440122 | 0.75 | MAPT (0.50) | MAPTGFERKDM4EGAAALDH1A1 | |
| SCHEMBL24681690 | 0.74 | MCHR1 (0.54) | MAPTALDH1A1KMT2AMCHR1HTT | |
| SCHEMBL9310257 | 0.74 | MAPT (0.46) | MAPTGFERKDM4EGAAALDH1A1 | |
| SCHEMBL24681691 | 0.74 | MCHR1 (0.54) | MAPTALDH1A1KMT2AMCHR1HTT | |
| SCHEMBL5924885 | 0.74 | KDM4E (0.43) | MAPTGFERKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |