Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 6/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.59 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.59 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.59 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528866 | 0.86 | EGFR (0.67) | KDREGFRRETIRAK4GAK | |
| SCHEMBL3528731 | 0.85 | KDR (0.68) | KDRAURKBAURKAEGFR | |
| SCHEMBL6161811 | 0.81 | HDAC3 (0.62) | KDREGFRRETIRAK4GAK | |
| SCHEMBL6163655 | 0.81 | HDAC3 (0.62) | KDREGFRRETIRAK4GAK | |
| SCHEMBL5473733 | 0.81 | KDR (0.74) | KDRAURKBAURKAEGFRRET | |
| SCHEMBL18158156 | 0.80 | AURKB (0.80) | KDRAURKBAURKAEGFRRET | |
| SCHEMBL6162849 | 0.80 | HDAC3 (0.57) | KDRAURKBAURKAEGFRRET | |
| Hydrochloric Acid SCHEMBL5477767 | 0.80 | EGFR (0.73) | KDRAURKBAURKAEGFRRET | |
| SCHEMBL5569469 | 0.80 | KDR (0.72) | KDRAURKBAURKAEGFRRET | |
| SCHEMBL5864703 | 0.79 | EGFR (0.84) | KDREGFRRETIRAK4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709479-B1 | Quinazoline derivatives and their use as pharmaceuticals | ASTRAZENECA (SE) | 2010-05-04 | — | — | US | disclosed |
| EP-1218354-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021596-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |