Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.76 |
| ▸ | PIM1 | P11309 | 2/20 | 0.76 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.76 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.76 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.76 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.76 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.76 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.76 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.76 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.76 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.76 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.76 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.76 |
| ▸ | PARP1 | P09874 | 16/20 | 0.71 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580297 | 0.94 | MAP4K4 (0.77) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL27743013 | 0.87 | PARP1 (0.77) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL3577816 | 0.86 | MAP4K4 (1.00) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL3578575 | 0.86 | PIM1 (0.77) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL6584116 | 0.85 | DYRK3 (0.56) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL3577449 | 0.85 | PIM1 (0.82) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL4321727 | 0.83 | PARP1 (1.00) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL3575207 | 0.83 | DYRK3 (0.53) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL3584420 | 0.82 | MAP4K4 (0.66) | MAP4K4PIM1PIM3AURKBCLK4 | |
| SCHEMBL13225609 | 0.81 | MAP4K4 (0.67) | MAP4K4PIM1PIM3AURKBCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |