Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580302 | 0.94 | DYRK3 (0.54) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3577822 | 0.86 | MAP4K4 (0.72) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3578582 | 0.86 | CHEK2 (0.56) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3577456 | 0.85 | MAP4K4 (0.59) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL31053400 | 0.83 | PARP1 (0.67) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3575199 | 0.83 | MAP4K4 (0.76) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL3584427 | 0.82 | DYRK3 (0.47) | DYRK3MAP4K4PIM1RPS6KB1CSNK2A1 | |
| SCHEMBL7136552 | 0.80 | PARP1 (0.52) | PIM1PIM3AURKBPARP1 | |
| SCHEMBL3581473 | 0.79 | DRD2 (0.62) | CHEK2PARP1 | |
| SCHEMBL3585144 | 0.78 | PARP1 (0.64) | MAP4K4PIM1AURKBHIPK2MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |