Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.90 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.90 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.90 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.90 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.90 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.90 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.90 |
| ▸ | GSK3A | P49840 | 2/20 | 0.90 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.90 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.90 |
| ▸ | LCK | P06239 | 1/20 | 0.90 |
| ▸ | CSF1R | P07333 | 1/20 | 0.90 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.90 |
| ▸ | MARK3 | P27448 | 1/20 | 0.90 |
| ▸ | KDR | P35968 | 1/20 | 0.90 |
| ▸ | FLT3 | P36888 | 1/20 | 0.90 |
| ▸ | CLK2 | P49760 | 1/20 | 0.90 |
| ▸ | ITK | Q08881 | 1/20 | 0.90 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.90 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575237 | 0.95 | MAP4K4 (1.00) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3578575 | 0.90 | PIM1 (0.77) | PIM1PIM3AURKBCLK4MAP4K4 | |
| Hydrochloric Acid SCHEMBL6806010 | 0.87 | AURKB (0.69) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL6579002 | 0.86 | MAP4K4 (0.68) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3580315 | 0.85 | MAP4K4 (0.82) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3577449 | 0.85 | PIM1 (0.82) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL16366311 | 0.85 | PARP1 (0.76) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3575819 | 0.84 | CHEK1 (0.65) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL6805282 | 0.84 | PIM1 (0.70) | PIM1PIM3AURKBCLK4MAP4K4 | |
| SCHEMBL3580805 | 0.83 | MAP4K4 (0.79) | PIM1PIM3AURKBCLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |