Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.65 |
| ▸ | MARK3 | P27448 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | GSK3A | P49840 | 1/20 | 0.65 |
| ▸ | ITK | Q08881 | 1/20 | 0.65 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.65 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.65 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.65 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3575241 | 0.95 | MAP4K4 (0.72) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL3578582 | 0.90 | CHEK2 (0.56) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL3580322 | 0.85 | CHEK1 (0.61) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL3577456 | 0.85 | MAP4K4 (0.59) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL6805290 | 0.84 | PIM1 (0.50) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL3575812 | 0.84 | PIM1 (0.90) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL3580810 | 0.83 | CHEK1 (0.59) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL6806295 | 0.82 | AURKB (0.55) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL6803462 | 0.80 | AURKB (0.48) | CHEK1MAP4K4LCKCSF1RPIM1 | |
| SCHEMBL6809867 | 0.80 | CLK4 (0.42) | CHEK1MAP4K4LCKCSF1RPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |