Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576133 | 1.00 | MRGPRX4 (0.40) | MRGPRX4KCNH2ABCB1NR3C1CSF1R | |
| SCHEMBL3287965 | 0.94 | KCNH2 (0.38) | MRGPRX4KCNH2ABCB1NR3C1CSF1R | |
| SCHEMBL3287963 | 0.94 | KCNH2 (0.38) | MRGPRX4KCNH2ABCB1NR3C1CSF1R | |
| SCHEMBL3290827 | 0.94 | KCNH2 (0.42) | KCNH2ABCB1NR3C1CSF1RPRMT5 | |
| SCHEMBL3290825 | 0.94 | KCNH2 (0.42) | KCNH2ABCB1NR3C1CSF1RPRMT5 | |
| SCHEMBL3286751 | 0.93 | KCNH2 (0.39) | MRGPRX4KCNH2NR3C1PRMT5WDR77 | |
| SCHEMBL4804569 | 0.93 | KCNH2 (0.40) | KCNH2ABCB1NR3C1CSF1RPRMT5 | |
| SCHEMBL4804580 | 0.93 | KCNH2 (0.40) | KCNH2ABCB1NR3C1CSF1RPRMT5 | |
| SCHEMBL4804593 | 0.93 | KCNH2 (0.40) | KCNH2ABCB1NR3C1CSF1RPRMT5 | |
| SCHEMBL4802793 | 0.93 | KCNH2 (0.40) | KCNH2ABCB1NR3C1CSF1RPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | SANOFI-AVENTIS (FR) | 2010-03-25 | — | — | US | disclosed |
| US-7625929-B2 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use thereof in therapeutics | SANOFI-AVENTIS (FR) | 2009-12-01 | — | — | US | disclosed |
| US-7453010-B2 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI AVENTIS (FR) | 2008-11-18 | — | — | US | disclosed |
| EP-1511722-B1 | PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI AVENTIS (FR) | 2007-10-03 | — | — | EP | disclosed |
| EP-1511728-B1 | OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2007-03-14 | — | — | EP | disclosed |
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2006-05-11 | — | — | US | disclosed |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | SANOFI-AVENTIS (FR) | 2005-08-11 | — | — | US | disclosed |
| EP-1511728-A2 | OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPEUTICS | Sanofi-Aventis (FR) | 2005-03-09 | — | — | EP | disclosed |
| EP-1511722-A1 | PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003099772-A1 | PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2003-12-04 | — | — | WO | disclosed |
| WO-2003099819-A2 | OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2003-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100283-A1 | Phenylcyclohexylpropanolamine derivatives, preparation and therapeutic application thereof | CHRM1, CHRM2, C1R | MRGPRX4 159/4885KCNH2 905/4885ABCB1 281/4885 |
| US-20100075986-A1 | Oxophenyl-Cyclohexyl-Propanolamine Derivatives, Production And Use Thereof In Therapeutics | HRH4, HRH3, AOC3 | MRGPRX4 191/4885KCNH2 136/4885ABCB1 306/4885 |
| US-20050176731-A1 | Oxophenyl-cyclohexyl-propanolamine derivatives, production and use therof in therapeutics | HRH4, HRH3, HTR3C | MRGPRX4 135/4885KCNH2 353/4885ABCB1 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.